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In the same model of asthma, a chimeric peptide constructed from modified NT and endomorphin-2 pharmacophores also reduced airway hyperresponsiveness, inflammatory cells influx in BALF, concentration of mouse mast cell protease, malondialdehyde, NF-B expression and secretory phospholipase 2 activity in lung tissue, as well as production of pro-inflammatory cytokines in BALF and lung [26]

AOD-9604 does not affect the hypothalamic-pituitary axis, so there is no negative feedback loop to blunt the response over time

Tominaga, T., Shimada, R., Okada, Y., Kawamata, T

To overcome these limitations and improve our understanding of wound healing, recent years have seen the emergence of innovative strategies including stem cell-based therapies, ECM-based strategies, nanotherapeutics, and multiomics approaches aiming to promote safe, efficient, and tailored healing of chronic wounds

Key Cited Studies Monnier M, Dudler L, Gchter R, Schoenenberger GA (1977) Delta-sleep inducing peptide (DSIP): EEG and motor activity in rabbits following intravenous administration