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The before state matters as much as the after

For example, glomerular endothelial cells, podocytes, or tubular epithelial cellsall involved in IgA nephropathy pathogenesismay also undergo ferroptosis or modulate mesangial cell ferroptosis via paracrine signaling, yet their roles in amplifying renal injury remain unaddressed

with some modifications

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Request for Comment on Dental Services Integral to Specific Covered Services To Treat Systemic Autoimmune Disease Requiring Immunosuppressive Therapies We have received information from interested parties, including submitters providing evidence through the public submissions process as well as commenters on prior proposed rules suggesting that certain dental services are inextricably linked to immunosuppressive therapies for individuals with autoimmune disorders