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There are still many lingering questions as to how they exert their biological effects, and whether they can exert such effects alone or in combination with the concomitant metabolic changes linked to ketone body increase

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This is critical to supply the brain cells with oxygen, energy, metabolites, and nutrients, as well as remove carbon dioxide and other metabolic wastes from the brain to the systemic circulation (Sweeney et al., 2018

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