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Omar, Elmesallamy, and Eassa 2005

First, the paracellular pathway: IFN- and TNF- activate the NF-B signaling pathway, leading to downregulation of tight junction proteins (claudin-5, occludin, and ZO-1) in cerebrovascular endothelial cells and triggering caspase-3/9-mediated tight junction remodeling

Milk thistle (also called holy thistle, Mary thistle, Marian thistle, or ladys thistle) is a herbal remedy derived from a plant called Silybum marianum or Carduus marianus