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10.1007/s12035-014-8833-3 145 QuirkB

Due to high levels of a UV-A chromophore in the lens (122) that mimics that of the human UV filter, a similar pattern of lens GSH distribution with lower levels of GSH in the nucleus relative to the cortex (183), and a similar age-dependent pattern of nuclear disulfide formation (184), it is proposed that guinea pigs are the best non-primate model currently available for the study of UV-A exposure and cataract ( However, while there are many benefits to the use of guinea pigs as a model of human UV exposure, it is also important to consider inconsistencies between humans and guinea pigs

Belfort R, Harrison SA, Brown K, Darland C, Finch J, Hardies J, et al

CKD is one of the prevalent human disorders associated with NLRP3 dysregulation, which, in turn, compromises the ability of host immune system to fight infections

Quercetin chelates metals and disrupts the STAT1/PPAR balance, promoting M2 polarization [528]