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In AD model mice, defects in autophagic lysosomal (AL) acidification precede A deposition, and the accumulation of A and amyloid beta precursor protein-C-terminal fragment in insufficiently acidified AL forms a PANTHOS [(poisonous anthos (flower))] pattern and develops into senile plaques, underscoring the critical role of AL dysfunction within neurons [145]

The most common types include cancers of the lung, breasts, colon and rectum, prostate, skin, and stomach

Epub 2012 Mar 6