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2012 Jun Annika van Hummel, Goce Taleski, JeanMarie Sontag, Astrid Feentje Feiten, Yazi D Ke, Lars M Ittner, Estelle Sontag

Demonstrates the role of pericytes in establishing the BBB and shows that barrier function is present even during the fetal period

For performance evaluation, a panel of known-mutagenic [ N -nitroso-dimethylamine (NDMA), N -nitroso-diethanolamine, N -nitroso-methylaniline, S N -nitroso-nornicotine, N-methyl-N-nitroso-2-propanamine] and reported non-mutagenic (methyl-t-butylnitrosamine, N -nitrosoproline) was tested, together with Nitrosamine Drug Substance-Related Impurities [ N -nitrosodesloratadine, N -nitrosofolic acid, N -nitrosofluoxetine (NFluo)] at a concentration range of 0.00510 mM

The findings revealed a 16% increase in the incidence of lung cancer among participants taking -carotene supplements