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Caution for vulnerable populations A 2016 literature review on artificial sweeteners in the Indian Journal of Pharmacology reported, there is inconclusive evidence to support most of their uses and some recent studies even hint that these earlier established benefits might not be true. Susceptible populations such as pregnant and lactating women, children, diabetics, migraine, and epilepsy patients should use these products with utmost caution. Review studies on non-sugar sweeteners Two review studies published in 2023 raised health concerns about the class of non-sugar sweeteners, which include acesulfame K, aspartame, advantame, cyclamates, neotame, saccharin, sucralose and stevia

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These achievements earned them the 1974 Nobel Prize in Physiology or Medicine