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An examination of the histologic effects of POL on the endothelium specifically, between 1 hour and 4 days after injection, illustrates the effect of varying the concentration of sclerosing solutions

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These were tested first in the statistical testing hierarchy, followed by the confirmatory secondary endpoints, which were tested in the following order: achievement of weight loss of at least 10% or 15% at week 104

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levamisole (alkaline phosphatase inhibitor), and dipyridamole (DYP, nucleoside transporter inhibitor)

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