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In fact, disulfide groups have been incorporated into different types of nanocarriers, such as polymeric micelles [38,39,44,59,60,62,63,65,66,67,68,69,110,111,112,113,114,115], liposomes [7,91,92,93,94,95,96,97,116], nanogels [64,98,99,100,101,102,103,104,105,106,107,108,109,117,118,119,120,121,122], hydrogels [123], mesoporous silica nanoparticles [61], metal-organic-frameworks [124], lipid nanoparticles [58], and hybrid DDSs combining two or more of these nanocarriers [32,125], among others

It resides between 1 and 2 in direct vicinity to the catalytic His190 and the gatekeeper Trp191 (Fig

This suggests potential applications in aging-related liver conditions like non-alcoholic fatty liver disease, where chronic metabolic stress combines with age-associated decline in hepatocyte function

In contrast, vehicle-treated MIA mice showed no significant change in their sociability scores