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It also modulates the FAK-paxillin pathway to drive fibroblast spreading and migration

Additionally, a preclinical study using a rabbit TB model showed that bevacizumab inhibited neovascularization, enhanced drug penetration into granulomas, improved lung pathology, and increased oxygenation, suggesting its potential to enhance the effectiveness of the current TB regimens [37]

Novel routes of drug delivery The therapeutic effect of a clinical condition is closely correlated with the administration route of a drug, and the efficacy of the same drug may vary greatly depending on the method of administration (Table 3) [132]

Plasma total cholesterol (Thermo Fisher Scientific, Infinity Total Cholesterol Reagent, TR13421), triglycerides (total glycerol and triglycerides) (Thermo Fisher Scientific, Infinity Total Triglycerides Reagent, TT22421), non-esterified fatty acids (NEFA) (Invitrogen, non-esterified free fatty acids (NEFA/FFA) Colorimetric Assay Kit, Thermo Fisher Scientific, EEA017), AST (Thermo Fisher Scientific, EEA003) and ALT (Thermo Fisher Scientific, EEA001) were quantified using enzymatic kits according to the manufacturers protocols

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