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Second, proline substitutions at positions 25, 28, and 29 reduce the tendency to form beta-sheet structures that lead to aggregation

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2000) and scientists are unable to provide a rational explanation for this discrepancy

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In CRC, PHGDH is markedly upregulated: Cullin 4A (Cul4A)-mediated PHGDH ubiquitination enhances its stability and activity, elevating SAM levels to promote metastasis via SETD1A-dependent histone methylation of cell adhesion genes (191)