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This section highlights key examples of TCM-derived metabolites that have made significant strides toward clinical translation, including berberine, quercetin, and the polyherbal Qili Qiangxin capsule, focusing on trial data, outcomes, and safety profiles ( 3.1 Clinical evidence and translational successes As a single-metabolite supplement, berberine has been used in East Asia for metabolic and cardiovascular health for decades, and Western interest has increased in recent years (Song et al., 2020)

Life Sci 88(1112):535542 Ilic S, Drmic D, Zarkovic K et al (2011b) Ibuprofen hepatic encephalopathy, hepatomegaly, gastric lesion and gastric pentadecapeptide BPC 157 in rats

Spatial mapping of the biologic effectiveness of scanned particle beams: towards biologically optimized particle therapy

Spelman T, Gray O, Trojano M et al (2014) Seasonal variation of relapse rate in multiple sclerosis is latitude dependent

Starting at 0.25mg weekly for the first four weeks, then increasing to 0.5mg for weeks 5-8, then to 1mg for weeks 9-12, and continuing to step up through 1.7mg and 2.4mg at four-week intervals