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Darkening of Skin and Gums: A peculiar side effect seen in about 1% of female trial participants was hyperpigmentation darkening of the gums or skin (particularly on the face and breasts)

Furthermore, combining CQDs with rhodamine 6G can be used to monitor glucose levels [110], where a change in colour from blue to green indicates an increase in glucose levels and has good selectivity for glucose over the major components in human blood and can be used with serum [110]