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Briefly, L-tryptophan is initially hydroxylated by tryptophan hydroxylase (TPH) to form 5-hydroxytryptophan (5-HTP) (Tan et al., 2016b), which is decarboxylated to produce 5-hydroxytryptophan (5-HT, serotonin) via aromatic amino acid decarboxylase (AADC) (Tan et al., 2015)

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