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For example, this disease is directly or indirectly responsible for approximately 4 million deaths per year, which corresponds to 9% of the total world mortality ( Obesity, IR and type 2 diabetes are closely related to sub-clinical and chronic inflammation, which is characterized by abnormal cytokine production, including an increase in acute phase molecules and other mediators, as well as inflammatory signaling pathway activation ( Within this inflammatory context, the liver may have an important contribution, because during overeating, which is common in obesity, it expresses and secretes several inflammatory proteins ( HGF synthesis and secretion are up-regulated in IR states, and is thought to be an important component of the pathophysiology of IR ( Structure and molecular biology of HGF and its receptor (c-Met) Originally, HGF was identified as a liver-regenerative circulating factor, since levels of this protein increased following liver injury or hepatectomy (1) ( Figure 1 The HGF locus is harbored on chromosome 7q21.1, covering approximately 70 kb and consists of 18 exons and 17 introns (56)

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Figure 4 1 has a broad and shallow surface around the key CDRH3 pocket (dashed circle), the pocket is deep, and narrow for Ab 2