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7 Epigenetic regulation strategies Chronic stress and inflammation can lead to epigenetic alterations in genes related to synaptic plasticity and inflammation

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Lactate could increase the concentration of the components of the malateaspartate shuttle, which increases the rate of transport of reducing equivalents to the mitochondrial matrix [178]

Non-mitochondrial ROS sources in diabetes Regardless of whether excessive ROS formation is the primary initiator or accompanying factor in the pathogenesis of diabetes mellitus, oxidative stress plays a key role in the organ complications such as cardiovascular problems, neurological problems (stroke), diabetic retinopathy, nephropathy, and neuropathy

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