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The investigational part is the combination strategy, the cagrilintide component, and the clinical question of whether amylin plus GLP-1 can become a next-generation obesity and diabetes platform

43 An upregulation of these alternative metabolic pathways mightin theoryexplain the association of increased levels of erythritol and xylitol with MACE, as hyperglycaemia and diabetes are known risk factors for MACE