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[Pyr 1 ]apelin-13 concentration was measured using an enzyme-linked immunosorbent assay (EK-057-23, Phoenix Pharmaceuticals, Burlingame, USA)

As such the overall impact of the manuscript would benefit greatly by detailed editing and potential re-organization. Response: As per your suggestion, we have replaced the section on requirements and detection of dimers with a reference to the original IUPHAR publication

Real-world US health records show the clinical uptake: the percentage of women with PMOS receiving at least one GLP-1 prescription rose from approximately 2% in 2021 to nearly 18% by 2025