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The intrinsic pathway, which is reliant on mitochondrial function, is initiated by various intracellular stimuli, including DNA damage, deprivation of growth factors, and oxidative stress

While uric acid (urate) is traditionally considered an antioxidant, it can act as a pro-oxidant in certain environments, especially in inflammatory disorders and oxidative stress conditions

1,2-Dibromoethane was an effective mitogen for liver under these experimental conditions (Nachtomi & Farber, 1978)

Curr Opin Pharmacol 2009, 9: 447453

For example, SufE1 and SufE3 are expressed in vegetative tissues while SufE2 is only expressed in pollen