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DNA methyltransferase inhibitors in cancer: from pharmacology to translational studies

In contrast, under oxidative stress conditions, Cys273 and Cys288 cysteines on Keap1 protein are rapidly oxidized, leading to the loss of Keap1 protein-mediated ubiquitination modifications and the translocation of Nrf2 to the nucleus, where it binds to multiple AREs on DNA and initiates the transcriptional expression of multiple antioxidant proteins [131]

The baseline clinical characteristics of the different groups are shown in Table 2

W.LashL.DekantW.ElfarraA

Figure 3 3.4 Identification of microbial protein groups We identified a total of 87 microbial proteins (Figure 4A