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ROS and RNS are known to cause DNA damage via oxidative processes

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The antioxidant activity of Que is excellent, and the phenolic hydroxyl groups rich in its structure can inactivate free radicals by providing active hydrogen while being oxidized to a more stable form of free radicals themselves ( 3+ to Fe 2+ ( 2+ is the key to the antioxidant activity of Que

The addition of exogenous ROS results in resensitization of cells with high VRK2 expression to GSH inhibition, which is consistent with the fact that PC cells with low expression of VRK2 are susceptible to GSH inhibition attributes to its high basal ROS level, suggesting that cells in a state of oxidative stress have enhanced dependence on the GSH system

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