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acknowledge University of Granada for the postdoctoral contract within the Plan Propio UGR and Dra

Overexpression of PINK1 can significantly upregulate Beclin1 and LC3 protein expression in an isoproterenol (ISO)-induced mouse cardiomyocyte injury model, decrease p62 protein expression, enhance myocardial mitophagy, and alleviate ISO-induced MMP reduction, ROS production, and cell apoptosis

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Furthermore, this PROTAC showed in vivo activity, being well-tolerated

However, recovery of gut microbiota by interrupting the treatment of antibiotics reversed these effects