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Studies have shown that when amyloid-beta and tau are increased, the cells ability to neutralize oxidative stress and mitochondria specific ROS is decreased leading to further tau hyperphosphorylation and neurodegeneration (Alavi Naini and Soussi-Yanicostas 2015)

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79 ItoW.KanehiroA.MatsumotoK.HiranoA.OnoK.MaruyamaH.et al (2005)

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