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Manic G, Obrist F, Kroemer G, Vitale I, Galluzzi L

Curr Opin Neurol 12:295302

Animal studies have shown that the BCL-2 family inhibitors ABT263 (Navitoclax) and ABT737 effectively eliminate SA--Gal-positive senescent cells, significantly enhancing the function of multiple systems and tissues, such as the haematopoietic and pulmonary systems, as well as skeletal muscle tissue [192, 212]

However, factors such as aging, poor diet, chronic stress, and environmental toxins can lead to decreased levels of glutathione

In addition, suppression of apoplastic H 2 O 2 production through SlRBOH1 silencing inhibited the induction of GSNOR activity, leading to SNO accumulation at high temperature (Figure 6)