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Recombinant GM-CSF administered by direct inhalation is currently being studied in a cohort of patients with advanced COVID-19

*Correspondence: Yujie He, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Additional inclusion criteria at screening were a pre-bronchodilator RV of 130% of predicted normal, moderate-to-severe COPD according to GOLD guidelines [post-bronchodilator (following inhalation of ipratropium bromide 68 g) forced expiratory volume in 1 s (FEV 1 ) between 30% and 125% of predicted normal), two LAMAsaclidinium bromide 400 g or glycopyrronium 50 g QD (both delivered via DPIs) reduced hyperinflation and dyspnea