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It catalyzes de novo pyrimidine ribonucleotide synthesis, and cancer cells proliferate and require more nucleotides, hence it has been investigated researched as cancer treatment [69].Metabolomic profiling studies have demonstrated the involvement of DHODH and mito-GPX4 in scavenging reactive oxygen species (ROS) and their unique roles in inducing apoptosis, irrespective of their usual function in nucleotide synthesis [18, 70]

Glyoxalase I inhibitor 7 can be used as anticancer agent

These results reflected the imbalanced inflammation homeostasis in PDR

However, directed differentiation of hepatocytes remains challenging