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Excess FFA influx initiates hepatic lipotoxicity, which induces endoplasmic reticulum (ER) stress, mitochondrial dysfunction, and inflammasome activation

10.1016/s0140-6736(22)01200-4 117 WangJ.SongR

Gold compounds may inhibit selenoproteins by targeting the Sec residue, and mammalian TrxR is a selenoprotein that is especially sensitive to such inhibition [29]

In the first 12-week trial, SGRQ responder rates at week 12 (defined as an improvement in score of 4 or more as a threshold) were 53%, 42%, and 31% for STIOLTO RESPIMAT, tiotropium 5 mcg, and placebo, respectively, with odds ratios of 1.6 (95% CI 1.1, 2.4) and 2.5 (95% CI 1.6, 3.8) for STIOLTO RESPIMAT vs

Chrysin inhibits ferroptosis of cerebral ischemia/reperfusion injury via regulating HIF-1/CP loop