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The critical role played by the Asp on position 1 of the motif is exemplified in the structure of the Clathrin box, where Asp 1 forms a salt bridge with K98 (Fig

They activate different intracellular signaling cascades (cAMP/PKA pathway in fat cells vs incretin signaling in gut and brain)

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10.1016/j.cell.2018.08.041 Summary Keywords GLP-1, gut microbiota, microbiome, pancreatic -cells, probiotics, single-cell transcriptomics, type 2 diabetes Citation Ruchko E, Chernysheva M, Sokolov V, Starinnov Z, Sabirov M and Vasiliev A (2026) -cell heterogeneity and molecular plasticity in type 2 diabetes: multi-omics perspectives and the role of gut microbiota

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