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The use of advanced techniques, such as computational mutagenesis, has been instrumental in identifying mutations that affect protein stability, which is crucial for understanding the underlying genetic causes of the deficiency

reduced proportion of morphologically normal sperm cells (teratozoospermia)

Su mecanismo de accin propuesto incluye la promocin de la angiognesis la formacin de nuevos vasos sanguneos a travs de la modulacin de la expresin del VEGF, un factor clave en los procesos de reparacin tisular

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This intermediate is subsequently reduced to mevalonate by HMG-CoA reductase (HMGCR), the key rate-limiting enzyme in cholesterol synthesis