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p53 promotes cancer cell adaptation to glutamine deprivation by upregulating Slc7a3 to increase arginine uptake

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Therefore, this study aimed to investigate whether COX-2 regulates ferroptosis via the Nrf2 signaling pathway during the progression of chronic liver injury

Underexplored epigenetic and long-term regulatory mechanisms: Epigenetic regulation of ferroptosis in AKI-to-CKD transition is largely limited to individual molecules (e.g., miRNAs targeting GPX4), with no comprehensive understanding of epigenetic landscapes (e.g., long non-coding RNAs, histone modifications, and DNA methylation) that persistently modulate ferroptosis-related genes during the chronic phase

Generally, injections / IVs are recommended once a week for 8 weeks to start