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10.1159/000493232 82 LiuZ.LiY.ZhuY.LiN.LiW.ShangC.et al (2022)

[31] [32] However, in 2003-2012, the National Institutes of Health (NIH) sponsored a $30 million controlled trial of chelation therapy, conducted by their National Center for Complementary and Alternative Medicine (NCCAM)

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However, in non-APL tumors, ATO faces a metabolic bottleneck that limits its efficacy, because a crucial aspect of ATOs pharmacological effects is that the parent compound is not the ultimate cytotoxic effector

Mice were treated with a neutralizing anti-NGF antibody for 1 h prior to the BSO injection and sacrificed 2 h later