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doi: 10.3389/fpls.2019.00290 72 KnstlerA.GullnerG.dmA

This effect is tightly dependent on the tumors enzymatic landscape, particularly IDO1 expression levels, which explains ICAs synergistic activity with anti-PD-1 therapy in both microsatellite instability-high (MSI-H) and microsatellite instability-low (MSI-L) CRC models (112)