lipoic acid glutathione reductase Antioxidant-enzyme Interaction in Non-communicable Diseases Glutathione-driven redox decisions in cell

Mitochondrial complex IVdeficient T cells maintain adequate superoxide production and activation, but antigen-driven responses in vivo are diminished by increased apoptosis, perhaps resulting from dysregulated cytochrome c release (15)

This might be due to the fact that in obese patients, adipocytes produce powerful pro-inflammatory cytokines like tumor necrosis factor- (TNF-) and IL-6, which in turn stimulate the secretion of CRP in the liver and endothelial cells (71)

These data demonstrate that changes in cellular metabolism, especially defects in mitochondrial function, are sufficient to promote dysfunction of T cells within the tumor microenvironment

2), Abstract 629-C (2023)

Front Biosci 10(13):11771182 Miguez-Pacheco V et al (2018) Development and characterization of niobium-releasing silicate bioactive glasses for tissue engineering applications