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One should consider the primary phase lesion and hemorrhaging that results from mechanical damage during SCI as well as the secondary phase lesion that lasts several hours or even several months and is accompanied by edema, hemorrhage, inflammation, and cytotoxic edema [44,45,46,47] and may extend to the white matter area and lead to white matter degeneration and damage [48, 49]

If using a particularly thin gauge needle (31G or smaller), consider using a slightly larger gauge (29G or 28G) for reconstitution, then switching to the finer needle for drawing doses

Selvarajah D, Kar D, Khunti K et al (2019) Diabetic peripheral neuropathy: advances in diagnosis and strategies for screening and early intervention

Ultimately, the traumatic lesions (subarachnoidal and intraventricular haemorrhage, brain laceration, haemorrhagic laceration) were less intense and consecutive brain edema had considerably improved (22)

Effect of angiotensin(17) and bradykinin in patients with heart failure treated with an ACE inhibitor