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In previous studies, cellular senescence has been considered a mechanism of preventing abnormal proliferation to malignancy in keloids and could be used to halt the progression of keloids 13

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[DOI] [PubMed] [Google Scholar] 15.Pereira A.C., Martel F

The external adverse elements, such as cigarette smoking, physical damage, and microbiota influence, may cause keratinocytes damaged through excessive production of ROS(Plenkowska et al., 2020)