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In the years immediately following the IOMs 1998 report setting the current RDA, research associated an abnormally high level of homocysteine, a molecule involved in protein metabolism, with an increased risk of cardiovascular disease, mortality, and cognitive impairment

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PBA can covalently bind to polymers and react with polyhydroxy substances to form glucose-responsive PBA ester bonds, while the catechol structure of the PBA ester impacts glucose responsiveness to the materials

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