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However, resistance to these drugs has been observed in many cases, necessitating to combine it with other drugs, such as tyrosine kinase inhibitors (TKIs) (imatinib, nilotinib) [5], taxanes (paclitaxel) [6], ribonucleotide reductase inhibitors (Gemcitabine) [7], phosphatidylinositol 3-kinase (PI3K) inhibitors (Alpelisib) [8], among others

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Another pharmacokinetic study reported that oxaliplatin concentrations were 3- to 4-times higher in tissue exposed to aerosol than in unexposed muscle at a dose of 90 mg/m 2 (Dumont et al., 2020)

doi: 10.1016/j.ymeth.2013.07.024 191 MalaninKLundbergMJohanssonSGO