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Tail-vein injection of parental, control and Grpr -expressing cells demonstrated that GRPR expression alone is sufficient to promote lung metastasis (Fig

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Furthermore, some researchers have used nano-cascade engineering to construct metal-organic supermolecules with p53-activating peptides and CeO 2 nanoparticles, which can activate the p53 signaling pathway and down-regulate the downstream gene GPX4 in vitro and in vivo, thereby inhibiting the development and progression of lung cancer [106]

199 Mitochondrial dysfunction may play an important role in the pathogenesis of ALS, which makes it a potential novel therapeutic target of intervention for ALS