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While Alnylams Phase III APOLLO-B study hit both key primary and secondary endpoints, the FDA stated in the documents that the effects of patisiran compared to placebo on both endpoints were small, of questionable clinical meaningfulness, and may not be detectable by patients. Major discussion points during the adcomm meeting included whether these key endpoints were appropriate to ascertain clinical meaningfulness in the ATTR-CM population, and panelists expressed varying opinions on whether the magnitude of the benefit seen in trial data was clinically meaningful

This dosage is 5 times the recommended dosage and 3 times the recommended therapeutic regimen

Next, 2,000 variable features were selected using the vst method implemented in the FindVariableFeatures function in Seurat

Androgen levels remain higher among women with PCOS as they age than among similarly aged women without PCOS

2.5 Characterization of surface morphology The surface morphology of the PLGA/CNT-lam scaffolds, PCL conduits, and the whole structure of conduits were analyzed by scanning electron microscopy (SEM, XL 30, Philips, USA)