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Disruptions to Core Clock Genes (Basic Science) Disruptions to core circadian clock proteins, specifically Bmal1 , has also resulted in increased reactive oxygen species, which is critical during mediation/exacerbation of damage during reperfusion in ischemia (Peek et al., 2017)

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Therefore, acid-base balance is maintained (mainly, but not exclusively) by the lungs (removing CO2), the liver (metabolism of organic acids), and the kidneys (excretion of nonvolatile acids)