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Thermal sensitivity testing demonstrated that as a group, at baseline, the subjects exhibited a reduction of function of cold detection threshold of all three regions tested, and reduced function in warm detection threshold in the foot and hand (Figure 7)

These moieties are subsequently excreted in the urine 7,8

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Simeon A, Wegrowski Y, Bontemps Y, Maquart FX

For example, post-acquisition administration of PregS is associated with improved retention in rodents on a passive avoidance paradigm, indicating that this positive modulator of glutamatergic neurotransmission facilitates consolidation (206)