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The secretion of glycosylated proIGF-1Ea and mature IGF-1 was also substantially affected by the inhibition of N-glycosylation (Figs 3C, 4B and S5B)

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Once trapped in an abnormal state, this can lead to body-wide problems [72]

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Patients with active or recent malignancy warrant particularly careful evaluation given the theoretical concerns that apply to any compound with effects on cellular metabolism

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