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B-100 complex can interfere with other medicines including but not limited to: levodopa, medicines containing oestrogen, hydrazine, certain anti epileptic drugs, phenobaritone, phenytoin, immunosuppressants and some drugs used to treat infections such as isoniazid, pyrazinamide, cycloserne and penicillamine

The theory behind the effectiveness of this treatment involves the effect of glucose on the capsaicin receptor TRPV1

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Giving yourself a clean baseline for a few weeks makes the whole process less confusing and a lot less uncomfortable

GLP-1 medications have substantially more long-term safety data, particularly for semaglutide which has been in widespread clinical use for over a decade across multiple indications