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For instance, L-Gln antagonists like acivicin, 6-Diazo-5-oxo-L-norleucine (DON), and azaserine caused significant gastrointestinal side effects and neurotoxicity

LT in larger laboratory animals such as dogs and pigs is technically easier

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However, the mechanism by which NQO1 mediates these functions is not yet well understood

For example, there may be a competition for glutamine between immune and tumor cells, and cell-programmed glutamine partitioning may happen between these cells in the TME