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Immune Dysfunction in Acute Undernutrition: Driver of Acute and Chronic Disease Outcomes Immune dysfunction in SAM predisposes children to acute infections including enteric and respiratory illnesses, measles and malaria, while survivors experience growth failure and long-term metabolic disorders [104,105,106] Both acute undernutrition and obesity precipitate micronutrient insufficiency, which exacerbates the severity of these conditions in mutually reinforcing cycles [51, 107,108,109] Enteropathy, characterized by gut mucosal degeneration, villous atrophy and impaired gut structure, occurs through a cascade of nutrient deficiency-induced biochemical, physiological and histological changes [108, 109]

Storage & stability How long it lasts, both before and after reconstitution The stability of bacteriostatic water and the reconstituted solution depends on the phase you are in: Unopened vial of bacteriostatic water: Store at room temperature, protected from direct light Shelf life according to the date on the packaging (typically months to years) Peptide reconstituted with bacteriostatic water: Store at 28 C (a standard refrigerator), protected from light Use within 14 to 30 days depending on the specific peptide More sensitive peptides (for example LL-37 or SS-31 ) may have shorter stability, follow the documentation for the given peptide Peptide reconstituted with sterile water without preservative: Substantially shorter shelf life, typically up to 7 days , since protection against microbial growth is absent Practical storage rules Let the vial warm to room temperature before opening (1520 min)