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[Abstract] Immunofluorescence staining to show the CTSK expression level in osteoclasts that were treated with Oligomycin A (10 nM), Rotenone (100 nM), FCCP (1 M), 2DG (1 M) or 3BrPA (3-Bromopyruvic acid, 1 M) for 6 h

This is consistent with another study which showed that Tanshinone IIA (Tan) inhibit atherosclerotic plaque formation in ApoE -/- mice and it is suggested that Tan regulates cholesterol metabolism by reducing the expression of SR-A, while further enhancing ABCA1 and ABCG1 expression in human THP-1 cells via activation of ERK/Nrf2/HO-1 pathway (Liu et al., 2014)

The MPP+-induced SH-SY5Y (a commonly used PD model) cell line is not programmed cell death and shares some similarities with iron toxicity: both involve lipid peroxidation and can be inhibited by DIM and Fer1 suppressed

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Accordingly, for clinical-stage PROTACs, selectivity is more appropriately understood primarily at the levels of target engagement and degradation profile, whereas strict cell-type selectivity is not generally considered an intrinsic property