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In contrast, quinolinic acid can induce cytotoxicity in neurons by hindering astrocyte glutamate reuptake (Stone and Perkins, 1981)

Proc Natl Acad Sci U S A (2018) 115:928893

These mainly include dyslipidemia and hypertension, that leads to a development of macro and microvascular complications

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Patients who are pregnant or breastfeeding, patients with active malignancy, patients with certain vascular conditions where angiogenesis is a concern, and patients on specific anticoagulants may not be candidates