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Additionally, phytobiotics activate the AMP-Activated Protein Kinase (AMPK) pathway (151)

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Plant Physiol 126:397410 Kusano T, Kim DW, Liu T, Berberich T (2015) Polyamine catabolism in plants

Mechanistic studies of neurodegenerative diseases, such as VaD and AD, have shown that pathological processes, including neuronal damage and synaptic loss, are strongly associated with ferroptosis (Adeniyi et al., 2023

In situ immunofluorescence of NRF2 also indicated this protein is highly expressed and present in the nucleus of A549 cells, with lesser expression in the nucleus of H23 cells (representative results shown in Supplementary Fig

Overall, these results confirmed the consistency of these antibodies used in the study and reinforce the conclusion that ferroptosis is the mode of cell death triggered in the lungs of patients with fatal COVID-19 disease