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Cigarette smoke-induced oxidative stress and pro-inflammatory responses disrupt airway epithelial barrier function and lead to impaired gas exchange in the lungs, which promotes systemic hypoxia and induces intestinal hypoxia, inflammation, mucosal angiogenesis and epithelial cell death, as well as reduced intestinal barrier function, which leads to an increased risk of gastrointestinal disease (61, 62)

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39 For HCV-HCC, early initiation of DAA therapy is advised, following the Guidelines for the Prevention and Treatment of Hepatitis C (version 2022)

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